Key result
The rs11646213 T allele is linked to ~36% higher preeclampsia risk in Han Chinese women.
Why the study?
Preeclampsia is a multifactorial disease influenced by genetic factors, and the association between rs11646213 and preeclampsia had not been evaluated in Han Chinese women.
Is the rs11646213 variant associated with an increased risk of preeclampsia in Han Chinese women?
Case-Control (n=914)
No
Is the rs11646213 variant associated with an increased risk of preeclampsia in Han Chinese women?
Answers are grounded in this paper and cite their sources.
The T allele of the rs11646213 variant upstream of the CDH13 gene is associated with an increased risk of preeclampsia, particularly severe and early-onset forms, in Han Chinese women.
BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP) rs11646213 was genotyped by polymerase chain reaction (PCR) and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76). Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03) and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13). Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.
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Wan et al. (2013) conducted a case-control in Preeclampsia (n=914). rs11646213 variant (T allele) vs. Normotensive pregnant women was evaluated on Association of rs11646213 minor allele frequency with preeclampsia (OR 1.36, 95% CI 1.06-1.76, p=0.017). The T allele of the rs11646213 variant was significantly associated with an increased risk of preeclampsia in Han Chinese women (OR 1.36).
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