Key result
CARD8 rs2043211 T allele linked to ~33% greater preeclampsia risk in the Chinese Han population.
Why the study?
The association between CARD8 rs2043211 polymorphism and susceptibility to preeclampsia in the Chinese Han population was unclear.
Is the CARD8 rs2043211 polymorphism associated with susceptibility to preeclampsia in the Chinese Han population?
Case-Control (n=712)
Is the CARD8 rs2043211 polymorphism associated with susceptibility to preeclampsia in the Chinese Han population?
Odds Ratio: 1.331 (95% CI 1.072–1.652)
p-value: p=0.009
The CARD8 rs2043211 polymorphism (T allele) is identified as a potential genetic susceptibility factor for preeclampsia in the Chinese Han population.
May inform preeclampsia risk stratification in Chinese Han women; hypothesis-generating and should not yet change practice.
OBJECTIVE: The purpose of our study was to investigate the association between polymorphism of rs2043211 in CARD8 and susceptibility to preeclampsia (PE) in the Chinese Han population. METHODS: 261 PE patients and 451 controls were genotyped for rs2043211 with the method of TaqMan allele discrimination assays. Clinical data were collected to perform genotype-phenotype analysis. RESULTS: Our study suggested that the rs2043211 variant was associated with the development of PE in the Chinese Han population. The genotypic and allelic frequencies differed significantly between the two groups (x03C7;2 = 8.198, p = 0.017 by genotype; x03C7;2 = 6.741, p = 0.009 by allele). The T allele was the risk allele for predisposition to PE (OR = 1.331, 95% CI 1.072-1.652). CONCLUSION: The polymorphism of rs2043211 in CARD8 may be a relevant host susceptibility factor for the development of PE in the Chinese Han population.
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Wang et al. (2015) conducted a case-control in Preeclampsia (n=712). CARD8 rs2043211 polymorphism (T allele) vs. Controls was evaluated on Predisposition to preeclampsia (OR 1.331, 95% CI 1.072-1.652, p=0.009). The T allele of the CARD8 rs2043211 polymorphism was associated with an increased susceptibility to preeclampsia in the Chinese Han population (OR 1.331; 95% CI 1.072-1.652; p=0.009).
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