Key result
Atg7 rs1375206 C allele linked to ~33% higher preeclampsia risk versus the G allele.
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Why the study?
The association between Atg7 rs1375206 polymorphism and preeclampsia risk in the Chinese Han population remains unclear.
Is the Atg7 rs1375206 genotype associated with susceptibility to preeclampsia in the Chinese Han population?
Case-Control (n=1,994)
Is the Atg7 rs1375206 genotype associated with susceptibility to preeclampsia in the Chinese Han population?
Odds Ratio: 1.33 (95% CI 1.17–1.51)
p-value: p=<0.001
The Atg7 rs1375206 polymorphism is significantly associated with preeclampsia risk in the Chinese Han population and may serve as a potential genetic marker.
Should not yet guide preeclampsia risk assessment; leaves open ATG7 rs1375206 as a hypothesis-generating biomarker pending replication.
Preeclampsia (PE) is linked to placental dysplasia and autophagy disorder. Atg7 is vital for placental development, yet its rs1375206 polymorphism with PE risk in Chinese Han population remains unclear. This study enrolled 990 PE patients and 1004 controls to genotype Atg7 rs1375206. Results revealed that this genetic variant was associated with susceptibility to preeclampsia (PE). Under the dominant genetic model (GG versus CG + CC, OR = 0.76, 95% CI 0.63-0.91, P = 0.003), carriers of the GG genotype exhibited lower PE risk compared with individuals carrying at least one C allele. Allelic comparison further verified that the C allele increased disease susceptibility compared with the G allele (OR = 1.33, 95% CI 1.17-1.51, P < 0.001). The recessive model (CC versus CG + GG, OR = 1.64; 95% CI, 1.29-2.07; P < 0.001) additionally confirmed a higher disease risk among CC homozygotes. The codominant comparison (CC vs CG vs GG) showed no significant difference in PE risk between CG heterozygotes and GG homozygotes (P = 0.102), whereas CC homozygotes exhibited substantially elevated risk relative to both CG heterozygotes and GG homozygotes (CC vs CG: OR = 1.52, 95% CI 1.19-1.95, P < 0.001; CC vs GG: OR = 1.79, 95% CI 1.39-2.32, P < 0.001). Stratified analysis showed differences in PE severity and onset subgroups. Bioinformatics and IHC confirmed reduced Atg7 expression in PE placentas. Atg7 rs1375206 may be associated with PE risk and serve as a potential genetic marker.
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Cheng et al. (2026) conducted a case-control in Preeclampsia (n=1,994). Atg7 rs1375206 C allele vs. G allele was evaluated on Preeclampsia susceptibility (OR 1.33, 95% CI 1.17-1.51, p=<0.001). The Atg7 rs1375206 C allele significantly increased the risk of preeclampsia compared with the G allele in the Chinese Han population (OR 1.33; 95% CI 1.17-1.51; P<0.001).
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