Key result
Intrathecal administration of 5 mg isobaric bupivacaine with 15 µg fentanyl reduced the incidence of intraoperative hypotension to 27.5% compared to 52.5% with 7 mg bupivacaine in patients undergoing caesarean section.
Why the study?
The study was conducted to examine the hemodynamic impacts of two different doses of intrathecal isobaric bupivacaine (5 mg vs 7 mg) combined with 15 µg fentanyl in patients undergoing caesarean section under combined spinal epidural anesthesia.
Does 5 mg isobaric bupivacaine reduce intraoperative hypotension compared to 7 mg isobaric bupivacaine in patients undergoing elective caesarean section?
Comparison
Intrathecal 5 mg isobaric bupivacaine plus 15 µg fentanyl vs 7 mg isobaric bupivacaine plus 15 µg fentanyl
Design
Randomized controlled trial
Authors
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Supports lower-dose spinal anesthesia for caesarean delivery to limit hypotension; extends RCT evidence for bupivacaine dose optimization.
RCT (n=80)
Double-blind
Computer-generated sequence of numbers
No
Does 5 mg isobaric bupivacaine reduce intraoperative hypotension compared to 7 mg isobaric bupivacaine in patients undergoing elective caesarean section?
Absolute Event Rate: 27.5% vs 52.5%
p-value: p=0.022
Intrathecal administration of 5 mg isobaric bupivacaine with 15 µg fentanyl provides adequate anaesthesia with significantly less hypotension compared to a 7 mg dose in patients undergoing caesarean section.
Dostbil et al. (2023) conducted an RCT in Elective caesarean section (n=80). Isobaric bupivacaine vs. 7 mg isobaric bupivacaine combined with 15 µg fentanyl was evaluated on Intraoperative systolic blood pressure (reported as incidence of hypotension) (p=0.022). Intrathecal administration of 5 mg isobaric bupivacaine with 15 µg fentanyl reduced the incidence of intraoperative hypotension to 27.5% compared to 52.5% with 7 mg bupivacaine in patients undergoing caesarean section.
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