Familial Amyloid-producing Medullary Thyroid Carcinoma and Pheochromocytoma

Article1 December 1965Familial Amyloid-producing Medullary Thyroid Carcinoma and PheochromocytomaA Distinct Genetic EntityR. NEIL SCHIMKE, M.D., WILLIAM H. HARTMANN, M.D.R. NEIL SCHIMKE, M.D., WILLIAM H. HARTMANN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-1027 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptConsiderable attention has of late been focused on heritable disorders of the endocrine system. The inborn errors of thyroid and adrenal metabolism have been fairly well characterized and have been the subjects of recent reviews (1, 2). Although the exact mode of inheritance remains to be established, diabetes mellitus appears to have a strong genetic component. Multiple endocrine adenomas, primarily involving pituitary, pancreas, and parathyroids, have also been described in multiple members of some families (3), and the syndrome appears to be genetically well defined (4). Pheochromocytoma has likewise been found to occur in familial aggregates, either alone (5) or...References1. STANBURY JB: Familial goiter, in The Metabolic Bases of Inherited Disease, edited by STANBURY, J. B., WYNGAARDEN, J. B., FREDRICKSON, D. S. McGraw-Hill, New York, 1960, p. 273. Google Scholar2. BONGIOVANNIROOT AMAW: The adrenogenital syndrome. New Eng. J. Med. 268: 1283, 1342, 1391, 1963. CrossrefMedlineGoogle Scholar3. BALLARDFRAMEHARTSOCK HSBRJ: Familial multiple endocrine adenoma-peptic ulcer complex. Medicine (Balt.) 43: 481, 1964. CrossrefMedlineGoogle Scholar4. WERMER P: Endocrine adenomatosis and peptic ulcer in a large kindred. Inherited multiple tumors and mosaic pleiotropism in man. Amer. J. Med. 35: 205, 1963. CrossrefMedlineGoogle Scholar5. 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Neil Schimke, M.D., Department of Medicine, Kansas University Medical School, Kansas City, Kan. 66103. 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ZELIS, M.D.Multiple mucosal neuromas, pheochromocytoma and medullary carcinoma of the thyroid—a syndromeSyndrome of Bilateral Pheochromocytoma, Medullary Thyroid Carcinoma and Multiple NeuromasON THE OCCURRENCE OF MONOAMINES AND RELATED SUBSTANCES IN FAMILIAL MEDULLARY THYROID CARCINOMA WITH PHAEOCHROMOCYTOMAPheochromocytoma and medullary carcinoma of thyroidGenetic Aspects of Clinical EndocrinologyPheochromocytomaAmyloidosisMedullary thyroid carcinoma, parathyroid adenoma, and bilateral pheochromocytomaHereditary Aspects of Some Less Frequently Occurring Malignancies Exclusive of The Reticuloendothelial System 1 December 1965Volume 63, Issue 6 Page: 1027-1039 Keywords Genetics Hospital medicine Inborn errors of metabolism Medical genetics Medullary thyroid carcinoma Pancreas Parathyroid Pheochromocytoma Thyroid Thyroid carcinoma ePublished: 1 December 2008 Issue Published: 1 December 1965 PDF downloadLoading ...