Deficiency of one or more anterior pituitary hormones may follow treatment with external radiation when the hypothalamic-pituitary axis falls within the fields of radiation. Hypopituitarism has been described in patients who received radiation therapy for nasopharyngeal carcinoma,1,2 tumors of the pituitary gland3,4 or nearby structures, and primary brain tumors,5,6 as well as in children who underwent prophylactic cranial irradiation for acute lymphoblastic leukemia or total-body irradiation for a variety of tumors and other diseases.On the basis of their studies of children and adults with brain tumors who underwent cranial irradiation, Constine et al. conclude in this . . .
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Steven M. Shalet (1993) studied this question.
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