Key result
Neurolept anaesthesia decreased right atrial pressure by 33% and pulmonary capillary wedge pressure by 36% in severe coronary artery disease, without depressing left ventricular performance.
Why the study?
Does an anaesthetic technique comprising phenoperidine, diazepam, and pancuronium bromide alter cardiovascular hemodynamics in patients with severe coronary artery disease?
Does an anaesthetic technique comprising phenoperidine, diazepam, and pancuronium bromide alter cardiovascular hemodynamics in patients with severe coronary artery disease?
A neurolept anaesthetic technique with phenoperidine, diazepam, and pancuronium bromide maintains stable hemodynamics without depressing left ventricular performance in patients with severe coronary artery disease.
May suggest hemodynamic stability with this technique in severe CAD; hypothesis-generating and requires prospective trials.
An anaesthetic technique comprising a combination of phenoperidine (0.1 mg . kg-1), diazepam (0.06 mg . kg-1) and pancuronium bromide (0.1 mg . kg-1) with controlled ventilation was evaluated in 12 patients with severe coronary artery disease. The heart rate, cardiac output and mean arterial blood pressure did not change significantly between the preinduction and postinduction measurements. The right atrial pressure and pulmonary capillary wedge pressure decreased significantly by 33% and 36%, respectively, probably due to the influence of positive-pressure ventilation. There was no depression of the left ventricular performance.
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Tydén et al. (1979) studied severe coronary artery disease (n=12). Neurolept anaesthesia (phenoperidine, diazepam, pancuronium bromide) vs. Preinduction measurements (baseline) was evaluated on Cardiovascular hemodynamics (heart rate, cardiac output, blood pressures). Neurolept anaesthesia decreased right atrial pressure by 33% and pulmonary capillary wedge pressure by 36% in severe coronary artery disease, without depressing left ventricular performance.
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