Key result
This review discusses advances in computational methods for vascular flow simulations in large arterial trees, comparing 3D and 1D models and exploring their clinical applications.
This review highlights the state-of-the-art in computational modeling of blood flow in large arterial trees, comparing 1D and 3D simulation approaches.
Advances in 1D/3D vascular simulations may guide research modeling; leaves open routine clinical use pending prospective validation.
Advances in computational methods and medical imaging techniques have enabled accurate simulations of subject‐specific blood flows at the level of individual blood cell and in complex arterial networks. While in the past, we were limited to simulations with one arterial bifurcation, the current state‐of‐the‐art is simulations of arterial networks consisting of hundreds of arteries. In this paper, we review the advances in methods for vascular flow simulations in large arterial trees. We discuss alternative approaches and validity of various assumptions often made to simplify the modeling. To highlight the similarities and discrepancies of data computed with different models, computationally intensive three‐dimensional (3D) and inexpensive one‐dimensional (1D) flow simulations in very large arterial networks are employed. Finally, we discuss the possibilities, challenges, and limitations of the computational methods for predicting outcomes of therapeutic interventions for individual patients.
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Anor et al. (2010) reported a review. This review discusses advances in computational methods for vascular flow simulations in large arterial trees, comparing 3D and 1D models and exploring their clinical applications.
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