Key result
Percutaneous management using alcohol septal ablation, BioGlue injection, and an Amplatzer vascular plug successfully reduced the peak LVOT gradient from 80 mmHg to 25 mmHg and improved mitral regurgitation from severe to mild.
Case Report (n=1)
No
Percutaneous management using alcohol and BioGlue septal ablation combined with vascular plug closure is a feasible alternative to high-risk repeat surgery for combined LVOT obstruction and paravalvular leak after surgical valve replacement.
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May support percutaneous options in select high-risk post-valve cases; hypothesis-generating and requires prospective validation before wider consideration.
Lee et al. (2015) conducted a case report in Left ventricular outflow tract obstruction and paravalvular leak post-valve replacement (n=1). Percutaneous septal ablation (alcohol and BioGlue) and paravalvular leak closure (Amplatzer vascular plug) was evaluated on Peak LVOT gradient and mitral regurgitation severity. Percutaneous management using alcohol septal ablation, BioGlue injection, and an Amplatzer vascular plug successfully reduced the peak LVOT gradient from 80 mmHg to 25 mmHg and improved mitral regurgitation from severe to mild.
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