The two nitrogen atoms in 1,8-di(3'-pyridyl)naphthalene were quaternized by the addition of either benzyl or methyl groups to give dications; the latter was oxidatively converted to the di(6'-pyridone). N-Oxidation gave the mono- and di-N-oxides. All these compounds in DMSO-d(6) show anti-syn atropisomerism at ambient temperatures by (1)H NMR analysis; similar amounts of both diastereomers are present.
No takes yet. Share an insight, caveat, or question.
Zoltewicz et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: