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In two dogs that received orthovoltage radiotherapy, osteosarcoma developed in irradiated bone 38 and 77 months after treatment. Irridiated bone in one dog was presumably normal prior to radiotherapy; irradiated bone in the other was infiltrated by an acanthomatous epulis. Both osteosarcomas were probably radiation induced. Radiation‐induced bone sarcoma is an important, but uncommon, complication of radiaotherapy.
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Thrall et al. (1983) studied this question.
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