Key result
ANGPTL3 overexpression suppressed the proliferation, migration, and invasion of renal cell carcinoma cells and inhibited the Wnt/β-catenin signaling pathway, correlating with better prognosis.
Why the study?
The expression pattern and functional roles of ANGPTL3 in renal cell carcinoma were rarely reported.
Does ANGPTL3 overexpression suppress oncogenic properties in renal cell carcinoma?
Population
RCC specimens from TCGA datasets and RCC cell lines
Comparison
ANGPTL3 overexpression vs low expression or controls
Design
In vitro and bioinformatic preclinical study
Authors
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May support ANGPTL3 as a prognostic marker in RCC; leaves open its therapeutic targeting in human studies.
Does ANGPTL3 overexpression suppress oncogenic properties in renal cell carcinoma?
ANGPTL3 overexpression suppresses renal cell carcinoma progression via the Wnt/β-catenin pathway and is associated with better patient prognosis.
Zhang et al. (2021) studied Renal cell carcinoma (RCC). ANGPTL3 overexpression vs. Low ANGPTL3 expression / control was evaluated on Cell proliferation, apoptosis, migration, invasion, and Wnt/β-catenin signaling activity. ANGPTL3 overexpression suppressed the proliferation, migration, and invasion of renal cell carcinoma cells and inhibited the Wnt/β-catenin signaling pathway, correlating with better prognosis.
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