Key result
The urinary angiotensinogen to urinary albumin ratio was significantly higher in patients with tubulointerstitial nephritis compared to those with IgA nephropathy (β=0.75, p<0.01).
Why the study?
The relative contributions of glomerular filtration versus proximal tubular production to urinary angiotensinogen levels in chronic kidney disease had not been clarified.
Population
41 biopsy-proven patients with IgAN (31), MN (5), or TIN (5) not taking RAS blockers
Comparison
IgA nephropathy vs membranous nephropathy vs tubulointerstitial nephritis
Design
Observational cross-sectional study
Authors
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May support urinary AGT/Alb as TIN biomarker in CKD; hypothesis-generating and requires prospective validation before clinical use.
Cross-Sectional (n=41)
No
Effect estimate: β=0.75
Absolute Event Rate: 4.36% vs 2.21%
p-value: p=<0.01
The urinary angiotensinogen to albumin ratio can help differentiate whether intrarenal renin-angiotensin system activation originates from glomerular filtration or proximal tubule production in CKD patients.
Ohashi et al. (2019) conducted a cross-sectional in Chronic kidney disease (IgA nephropathy, membranous nephropathy, tubulointerstitial nephritis) (n=41). Tubulointerstitial nephritis (tubulointerstitial damage) vs. IgA nephropathy and membranous nephropathy (glomerular damage) was evaluated on Urinary angiotensinogen to urinary albumin ratio (Log u-AGT/Alb in ng/mg) (β=0.75, p=<0.01). The urinary angiotensinogen to urinary albumin ratio was significantly higher in patients with tubulointerstitial nephritis compared to those with IgA nephropathy (β=0.75, p<0.01).
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