Key result
Low circulating adiponectin levels (<6 µg/mL) were independently associated with increased left ventricular mass index and a significantly higher prevalence of left ventricular hypertrophy and coronary artery disease.
Cross-Sectional (n=135)
No
Effect estimate: Beta -15.4
p-value: p=<0.001
Hypoadiponectinemia is independently associated with increased left ventricular mass and a higher prevalence of coronary artery disease, suggesting it may serve as a novel cardiometabolic biomarker.
May support adiponectin as a cardiometabolic biomarker; hypothesis-generating and requires prospective validation before clinical use.
This study was designed to evaluate the interaction between total adiponectin (ADPN) and metabolic syndrome (MetS) on cardiac changes in 135 subjects with and without MetS, subgrouped according to normal or low ADPN. Left ventricular internal diameter (LVID/h), LV mass (LVM), LVM index (LVMI), interventricular septal thickness (IVST), relative wall thickness (RWT) and LV ejection fraction (EF) by echocardiography and diastolic parameters, by pulsed-wave Doppler were calculated. BMI, LVM, LVMI, LVID/h, IVST and RWT values were significantly (p<0.05) higher in both groups with low ADPN. Prevalence of left ventricular hypertrophy (p<0.001) and coronary artery disease (p<0.01) was significantly higher in both low ADPN groups. LVMI correlated directly with BMI (p<0.001), (p<0.001), MetS (p<0.001) and inversely with ADPN (p<0.0001). ADPN and BMI resulted independently associated with LVMI. In conclusion, our data suggest that hypoadiponectinemia might be considered a novel “cardiometabolic biomarker”. Accordingly, circulating ADPN might become a new target in the management of cardiometabolic syndrome.
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Rosario Scaglione (2014) conducted a cross-sectional in Metabolic syndrome (n=135). Low adiponectin levels (<6 µg/mL) vs. Normal adiponectin levels (≥6 µg/mL) was evaluated on Left ventricular mass index (LVMI) (Beta -15.4, p=<0.001). Low circulating adiponectin levels (<6 µg/mL) were independently associated with increased left ventricular mass index and a significantly higher prevalence of left ventricular hypertrophy and coronary artery disease.
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