Key result
Endovascular aortic repair resulted in significantly lower blood endotoxin levels on postoperative day 3 compared to open abdominal surgery (0.26 vs 0.38, P=0.01).
Why the study?
Does endovascular aneurysm repair reduce postoperative blood endotoxin levels compared to open abdominal surgery in patients with abdominal aortic aneurysm?
Observational (n=14)
No
Does endovascular aneurysm repair reduce postoperative blood endotoxin levels compared to open abdominal surgery in patients with abdominal aortic aneurysm?
Endovascular aneurysm repair is associated with significantly lower postoperative blood endotoxin levels compared to open abdominal surgery, suggesting it is a less invasive procedure with reduced systemic inflammation.
Answers are grounded in this paper and cite their sources.
Endovascular repair was associated with lower endotoxin; hypothesis-generating for reduced inflammation, needs randomized confirmation before practice change.
Introduction: We hypothesized to demonstrate whether there are significant differences in blood endotoxin (Et) levels after abdominal aortic surgery between endovascular aortic repair (EVAR) and open abdominal surgery. Methods: The patients who underwent the surgical treatment for abdominal aortic aneurysm were divided into two groups according to the procedures: open abdomen surgery (OP) and EVAR (SG). The value of Endotoxin Activity Assay (EAA) was compared between groups. Results: After surgery, Et level was significantly higher in the OP group than in the SG group on postoperative day 3. Neutrophil count was significantly higher in the OP group immediately after treatment, but no significant difference was seen thereafter. There were no differences between the groups in other inflammatory markers. Conclusions: This study indicated that EVAR was less invasive compared to an open abdominal surgery from the standpoint of assessing postoperative endotoxin activity (EA) levels measured by EAA.
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Ohishi et al. (2014) conducted an observational in Abdominal aortic aneurysm (n=14). Endovascular aortic repair (EVAR) vs. Open abdominal surgery was evaluated on Blood endotoxin activity (EA) level on postoperative day 3 (p=0.01). Endovascular aortic repair resulted in significantly lower blood endotoxin levels on postoperative day 3 compared to open abdominal surgery (0.26 vs 0.38, P=0.01).
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