Key result
Total coronary artery volume measured by 64-slice MSCT was significantly correlated with left ventricular mass (r=0.660, P<0.0001), but the increase in volume was inadequate relative to the severity of hypertrophy.
Why the study?
Does coronary artery volume measured by 64-MSCT correlate with left ventricular mass in patients without significant coronary artery stenosis?
Observational (n=61)
No
Does coronary artery volume measured by 64-MSCT correlate with left ventricular mass in patients without significant coronary artery stenosis?
Effect estimate: r=0.660
p-value: p=<0.0001
64-MSCT can accurately measure coronary artery volume, demonstrating that epicardial coronary volume increases proportionally with left ventricular mass but inadequately relative to the severity of hypertrophy.
Coronary volume may lag LV mass in hypertrophy; leaves open whether MSCT assessment identifies ischemia risk.
BACKGROUND: Previous studies have shown a correlation between coronary artery cross-sectional diameter and left ventricular (LV) mass. However, no studies have examined the correlation between actual coronary artery volume (CAV) and LV mass. In the present study, measurements of CAV by 64-multislice computed tomography (MSCT) were validated and the relationship between CAV and LV mass was investigated. METHODS AND RESULTS: First, coronary artery phantoms consisting of syringes filled with solutions of contrast medium moving at simulated heart rates were scanned by 64-MSCT. Display window settings permitting accurate calculation of small volumes were optimized by evaluating volume-rendered images of the segmented contrast medium at different window settings. Next, 61 patients without significant coronary artery stenosis were scanned by 64-MSCT with the same protocol as for the phantoms. Coronary arteries were segmented on a workstation and the same window settings were applied to the volume-rendered images to calculate total CAV. Significant correlations between total CAV and LV mass (r=0.660, P<0.0001) were found, whereas an inverse relation was present between total CAV per 100 g of LV mass and LV mass. CONCLUSIONS: The novel concept of "CAV" for the characterization of coronary arteries may prove useful for future research, particularly on the causes of LV hypertrophy.
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Ehara et al. (2009) conducted an observational in Suspected coronary artery disease (n=61). Left ventricular mass was evaluated on Correlation between total coronary artery volume (CAV) and left ventricular (LV) mass (r=0.660, p=<0.0001). Total coronary artery volume measured by 64-slice MSCT was significantly correlated with left ventricular mass (r=0.660, P<0.0001), but the increase in volume was inadequate relative to the severity of hypertrophy.
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