Key result
MR-guided stereotactic body radiation therapy was feasible and well-tolerated in four patients with primary cardiac sarcomas, achieving 100% local control with only mild grade 1 or 2 toxicities at early follow-up.
Why the study?
Hybrid MR-guided radiation therapy enables better visualization and delivery of high doses per fraction to the heart, but its feasibility, early outcome, and toxicity in inoperable primary cardiac sarcomas required investigation.
Does MR-guided stereotactic body radiation therapy provide feasible local control with acceptable toxicity in patients with inoperable primary cardiac sarcomas?
Case Report (n=4)
Yes
Does MR-guided stereotactic body radiation therapy provide feasible local control with acceptable toxicity in patients with inoperable primary cardiac sarcomas?
MR-guided stereotactic body radiation therapy is a feasible and well-tolerated salvage treatment for recurrent primary cardiac sarcomas, showing early local control with minimal toxicity.
Answers are grounded in this paper and cite their sources.
Should not yet change practice in cardiac sarcomas; leaves open the need for prospective trials to confirm durability.
BACKGROUND: Primary cardiac tumors are an extremely rare disease with limited prognosis. The treatment of choice is surgery. Other treatment options include chemotherapy and radiation therapy, which historically represented a palliative approach in patients who were not eligible for surgery. The development of hybrid MR-guided radiation therapy makes it possible to better visualize cardiac lesions and to apply high doses per fraction in sensible organs such as the heart. CASE PRESENTATION: Patients affected by inoperable primary cardiac sarcomas and treated at two different institutions were considered for this analysis and retrospectively analyzed. All patients were treated using a 0.35 T hybrid MR Linac system (MRIdian, ViewRay Inc., Mountain View, CA). In the present study we investigated the feasibility, early outcome and toxicity of MR-guided RT in primary cardiac sarcomas. Four consecutive non-metastasized patients who were treated between 05-09/2020 were analyzed. The cardiac sarcomas were mostly located in the right atrium (50%) and one patient presented with 3 epicardial lesions. All patients received MRgRT as a salvage treatment for recurrent cardiac sarcoma after initial surgery, after a mean interval of 12 months (range 1-29 months). Regarding the treatment characteristics, the mean GTV size was 22.9 cc (range 2.5-56.9 cc) and patients were treated with a mean GTV dose of 38.9 Gy (range 30.1-41.1 Gy) in 5 fractions. Regarding feasibility, all treatments were completed as planned and all patients tolerated the treatment very well and showed only mild grade 1 or 2 symptoms like fatigue, dyspnea or mild chest pain at early follow-up. CONCLUSION: To the best of our knowledge, in this retrospective analysis we present the first and largest series of patients presenting with primary cardiac sarcomas treated with online adaptive MRgRT. However, further studies are needed to evaluate the impact of this new methodology on the outcome of this very rare disease.
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Corradini et al. (2021) conducted a case report in Primary cardiac sarcomas (n=4). MR-guided stereotactic body radiation therapy (MRgRT) was evaluated on Feasibility and early toxicity. MR-guided stereotactic body radiation therapy was feasible and well-tolerated in four patients with primary cardiac sarcomas, achieving 100% local control with only mild grade 1 or 2 toxicities at early follow-up.
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