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The rat lymphoma cell line was used to bioassay human GH (hGH) in 30 serum samples from 4 acromegalic patients and human PRL (hPRL) in 25 sera from 5 hyperprolactinemic patients. The ratio of the bioassay and RIA estimates of hGH was 0.96 ± 0.13 (mean ± SD) and of hPRL was 1.06 ± 0.14. There was no significant difference in the ratio of the bioassay and RIA estimates of hGH or hPRL during the time course of TRH tests in acromegalic or in hyperprolactinemic patients, respectively.
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Tanaka et al. (1983) studied this question.
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