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Cystic glandular hyperplasia of the endometrium was induced in castrate and entire guinea pigs by injecting oestradiol (15 ~tg per week), or by feeding them oestrogenically potent subterranean clover, for 7-8 weeks. The presence of the lesion was determined by removal of one uterine horn at biopsy from some of the animals at the end of the 7-8 weeks, after which all animals were left without treatment for a further period of 20 weeks.
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Braden et al. (1953) studied this question.
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