THE problem of pituitary ovarian interrelationships has been investigated extensively during the last three decades and there seems to be general agreement that large quantities of gonadal hormones will suppress gonadotrophic hormone secretion. However, there is considerable controversy concerning the quantitative aspect of the effect of gonadal hormones on the secretion of gonadotrophins. A most important consideration in this problem is whether or not estrogen inhibits the production of gonadotroplins when within physiological limits, and whether estrogen stimulates the production and/or release of gonadotrophic hormone. Some confusion results from the failure to distinguish between the gonadotrophic content of the pituitary and the amount of hormone being secreted by the gland. Although much work has been done on the effect of estrogen upon the amount of hormone within the gland, this may not always be a valid index of the secretion rate of the hormone.
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Byrnes et al. (1951) studied this question.