Demonstration of Increased Gonadotrophic Hormone Production in Castrated Mice with Intrasplenic Ovarian Grafts.

Evidence of an increased rate of production of gonadotrophins in castrated mice with intrasplenic ovarian grafts has been obtained by means of parabiotic experiments. The ovaries of normal mice placed in parabiosis with female littermates that had been castrated and had an ovary grafted into the spleen from 30 to 50 days previously averaged 37% heavier than the corresponding ovaries when parabolic was performed simultaneously with the other operations. The duration of parabolic ranged from 9 to 13 and from 11 to 35 days, in the 2 groups, averaging 11 days in the former and 17 days in the latter.