Key result
The mitochondrial DNA mutation 680insG is associated with chronic atrial fibrillation and generates a non-functional 318-amino acid polypeptide lacking its intracellular C-terminal region.
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May implicate mitochondrial dysfunction in chronic AF; hypothesis-generating and requires validation before clinical relevance.
N This mutation 680insG resulted in the subsequent generation of a non-functional short polypeptide (318 amino acids) that lacks its intracellular C-terminal region or well in a null allele.
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Park et al. (2007) studied this question. The mitochondrial DNA mutation 680insG is associated with chronic atrial fibrillation and generates a non-functional 318-amino acid polypeptide lacking its intracellular C-terminal region.
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