Why the study?
Is the presence of mitochondrial DNA deletions associated with reduced adenine nucleotides and atrial fibrillation in human atrial tissue?
Population
26 human right atria obtained at the time of cardiac surgery
Comparison
Presence of 7.4 kb mitochondrial DNA deletion vs Absence of mtDNA deletion
Design
Cross-sectional
Authors
Loading...
mtDNA deletion links to AF and atrial energy depletion but should not yet change practice; leaves open causal role versus consequence of aging.
Is the presence of mitochondrial DNA deletions associated with reduced adenine nucleotides and atrial fibrillation in human atrial tissue?
Mitochondrial DNA deletions in human atrial tissue are associated with aging, atrial fibrillation, and bioenergetic deficiency due to impaired ATP synthesis.
Tsuboi et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: