Calculations of total doses for different numbers of fractions are presented, for two special assumptions. One is based on published radiotherapy results, i.e. on normal tissue reactions and cure of squamous-cell carcindoma, together with experiments on the skin of pigs and mice. The other is based on a cell survival curve model with extrapolation number = 2·8 and D0 = 140 rads. Neither assumption allows fully for cell repopulation, and the significance of this is discussed. The limitations of the calculations as a guide to radiotherapeutic practice are stressed.
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Jack F. Fowler (1965) studied this question.
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