Experimental study demonstrates rhodium-catalyzed coupling of 4,4-dimethyl-2-oxazoline with alkenes, indicating a safer alternative to carbon monoxide-based hydroesterification.
A new method for the preparation of 2-substituted oxazolines by rhodium-catalyzed coupling of alkenes with 4,4-dimethyl-2-oxazoline is reported. The oxazoline products are obtained in good yield with excellent selectivity for the linear product. A variety of alkene substitution patterns and functional groups are tolerated. This procedure represents an attractive alternative to hydroesterification because it does not involve the manipulation of CO gas.
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Wiedemann et al. (2004) studied this question.
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