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Demonstrates efficient synthesis of isoxazoline N-oxides, highlighting new heterocycles.
A Pd(II)-catalyzed [3 + 2] annulation of alkenyl amides and nitroalkanes is described. The method furnishes intricately functionalized isoxazoline N- oxide products in a single step from simple starting materials, enabling expedient access to this underexplored class of heterocycles. With internal and α-functionalized olefins, the reaction proceeds with high diastereoselectivity, providing controlled entry into isoxazoline N- oxides with multiple stereogenic centers.
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Hu et al. (2026) studied this question.
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