November 20, 2025Synlett

Rhodium-catalyzed C–H annulation of aldonitrones with allyl methyl carbonate

View Full Paper

Ask AI

Bookmark

The C–H annulation process achieves high regioselectivity for isoxazolidines with a specific condensed ring structure.
Notably, the reaction utilizes allyl methyl carbonate and C-aryl-N-tert-butyl nitrones as key reagents in this sequence.
Employing a Rh(III) catalyst allows efficient nitrone-directed C–H activation, leading to effective allylation results.
These findings may enable the development of new synthetic routes for complex molecular architectures.

Implication

C–H activation and allylation yields polycyclic isoxazolidines in nitrone derivatives, suggesting regioselectivity benefits.

Abstract

Rh(III)-catalyzed, nitrone-directed C–H activation/allylation/1,3-dipolar cycloaddition sequence with C-aryl-N-tert-butyl nitrones and allyl methyl carbonate gives polycyclic isoxazolidines, in many cases with high or complete regioselectivity for products with a condensed ring system (containing a 1-amino-2-hydroxymethyl-indane skeleton).

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Stańska et al. (2025) studied this question.

synapsesocial.com/papers/6924f08cc0ce034ddc35073c https://doi.org/10.1055/a-2752-7699

View Full Paper

Ask AI

Bookmark

Implication

C–H activation and allylation yields polycyclic isoxazolidines in nitrone derivatives, suggesting regioselectivity benefits.

Rhodium-catalyzed C–H annulation of aldonitrones with allyl methyl carbonate

Key Points

Implication

Abstract

Discussion

Cite This Study

Rhodium-catalyzed C–H annulation of aldonitrones with allyl methyl carbonate

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading