Key result
Cofilin 1 expression was significantly upregulated in colorectal cancer tissues compared to adjacent non-tumor tissues (P<0.05), demonstrating a diagnostic area under the curve of 0.85.
Why the study?
Does cofilin 1 gene expression differ between colorectal cancer tissues and adjacent non-tumor tissues, and does it have diagnostic value?
Observational (n=30)
Does cofilin 1 gene expression differ between colorectal cancer tissues and adjacent non-tumor tissues, and does it have diagnostic value?
Cofilin 1 is significantly upregulated in colorectal cancer tissues compared to adjacent non-tumor tissues and may serve as a diagnostic biomarker.
May support cofilin 1 as CRC biomarker; hypothesis-generating and requires prospective validation.
BACKGROUND: Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Cofilin is a key regulatory protein in the dynamics of actin filaments. Previous studies have shown cofilin 1's major role in cell migration process and its role in tumor cell migration and invasion. Therefore, cofilin 1 may have the potential as a novel diagnostic tumor marker in various cancers. In this study, differential expression of CFL1 in CRC tissues in comparison with adjacent non-tumor tissues was investigated and the diagnostic value of this protein in CRC was evaluated. METHODS: Synthesized cDNA from extracted RNAs of 30 patients were subjected to qRT-PCR to quantify relative expression of cofilin 1. The relationship between cofilin 1 expression and clinicopathological features of patients were studied too. RESULTS: The study showed significant upregulation of cofilin 1 in CRC tissue samples compared to adjacent non-tumor tissue samples (P<0.05). The receiver operating characteristic curve analysis showed higher area under the curve (0.85). There was no significant correlation between cofilin 1 expression levels and clinicopathological features of patients. CONCLUSIONS: According to the obtained results, cofilin 1 can serve as a candidate for clinically useful diagnostic biomarker or therapeutic target for CRC.
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Mousavi et al. (2018) conducted an observational in Colorectal cancer (n=30). Cofilin 1 expression vs. Adjacent non-tumor tissues was evaluated on Relative expression of cofilin 1 and diagnostic value (AUC 0.85, p=<0.05). Cofilin 1 expression was significantly upregulated in colorectal cancer tissues compared to adjacent non-tumor tissues (P<0.05), demonstrating a diagnostic area under the curve of 0.85.
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