Key result
A novel 3'-end repair mechanism in turnip crinkle carmovirus involves the production of 4-8 nt oligoribonucleotides by abortive synthesis by the viral replicase to prime negative-strand synthesis.
Authors
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May inform models of viral RNA replication; leaves open conservation and therapeutic relevance across RNA viruses.
Nagy et al. (1997) studied RNA virus infection (Turnip crinkle carmovirus). Viral replicase-mediated 3'-end repair was evaluated on 3'-end repair of satellite RNA C. A novel 3'-end repair mechanism in turnip crinkle carmovirus involves the production of 4-8 nt oligoribonucleotides by abortive synthesis by the viral replicase to prime negative-strand synthesis.
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