Key result
Symptoms of type II amiodarone-induced thyrotoxicosis were successfully relieved following the withdrawal of amiodarone and the administration of steroids.
Case Report (n=1)
Type II amiodarone-induced thyrotoxicosis is a relatively rare complication that can be successfully managed by withdrawing amiodarone and administering steroids.
May support amiodarone withdrawal plus steroids in type II AIT; leaves open confirmation in controlled studies.
Amiodarone is an iodinated benzofuran derivative, that is highly effective as an agent for the treatment of various cardiac arrhythmias; these arrthymias, range from paroxysmal atrial fibrillation to life-threatening ventricular tachyarrhythmias. Yet amiodarone is associated with several side effects that include dysfunction of liver, thyroid or various other organs. Two main forms of amiodarone induced thyrotoxicosis (AIT) have been described; type I AIT develops in an abnormal thyroid gland (nodular goiter, latent Graves' disease) and it is due to amiodarone-induced true hyperthyroidism; type II AIT occurs in an apparently normal thyroid gland and it is due to amiodarone-induced destructive thyroiditis. We recently experienced a case of type II thyrotoxicosis that was induced by amiodarone treatment for ventricular tachycardia after acute myocardial infarction. The symptoms of thyrotoxicosis were relieved after withdrawal of amiodarone and administering steroid. Type I AIT has often been reported on but type II AIT is relatively rare. We report here on a case of type II amiodarone induced thyrotoxicosis along with a literature review.
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Ju et al. (2007) conducted a case report in Amiodarone-induced thyrotoxicosis (Type II) (n=1). Amiodarone withdrawal and steroid administration was evaluated on Relief of thyrotoxicosis symptoms. Symptoms of type II amiodarone-induced thyrotoxicosis were successfully relieved following the withdrawal of amiodarone and the administration of steroids.
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