Practical and Useful Methods for the Enantioselective Reduction of Unsymmetrical Ketones

All articles of this category Enantioselective reduction of unsymmetrical ketones to optically active alcohols is very important in organic synthesis. Catalytic methods have been developed for this process and have not been reviewed previously. In this article the recently developed oxazaborolidine catalyzed reduction along with other useful reagents will be discussed. 1. Introduction 2. Oxazaborolidines 3. B -3-pinanyl-9-borabicyclo[3.3.1]nonane 4. Chlorodiisopinocampheylborane 5. 2,5-Dimethylborolane 6. BINAL-H 7. BINAP-Ru Complex 8. Conclusion