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The influence of ancestry on inflammatory bowel disease (IBD) susceptibility has recently been examined via several large-scale genome-wide association studies,1,2 but the effects of ancestry-specific variation in risk and modifier gene expression on prognosis in IBD remain poorly characterized. It has been estimated fairly consistently that the prevalence of IBD is approximately 2 to 3 times greater in individuals of European versus African American (AA) descent,3 but the literature offers conflicting reports on complications and outcomes in AA versus European ancestry patients.
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Mo et al. (2020) studied this question.
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