What question did this study set out to answer?

To determine the prognostic utility of quantitative liver function breath tests during the progression of biliary cirrhosis and evaluate their relationship with hepatocyte mass.

May 1, 1987HepatologyOpen Access

The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: Correlation with morphometric measurement of hepatocyte mass

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Authors

JGJohn B. GrossJohns Hopkins University JRJuerg ReichenMonash University TZThomas ZeltnerUniversity of Bern

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Implication

Experimental study reveals breath tests predict imminent death and reflect functional hepatocyte mass in cirrhotic rats, suggesting serial testing tracks disease severity.

Key Points

To determine the prognostic utility of quantitative liver function breath tests during the progression of biliary cirrhosis and evaluate their relationship with hepatocyte mass.
Quantitated microsomal function using the aminopyrine breath test and cytosolic function using the galactose breath test weekly in bile duct-ligated cirrhotic rats (n = 14) and sham-surgery controls (n = 9).
Conducted morphometric measurements of hepatocyte mass and microsomal enzyme activity in surviving cirrhotic and control rats (n = 5 each).
Both the aminopyrine and galactose breath tests demonstrated 89% sensitivity in predicting death within 1 week, with the galactose breath test showing higher specificity at 83%.
Surviving cirrhotic rats maintained hepatocyte mass (17.0 ± 2.0 g vs. 13.9 ± 0.9 g in controls) and galactose breath test output, which correlated with hepatocyte mass (r = 0.67).
Aminopyrine breath test results declined significantly in surviving cirrhotic rats and correlated directly with microsomal aminopyrine N-demethylase activity (r = 0.78).

Cite This Study

Gross et al. (1987) studied this question.

synapsesocial.com/papers/6a9330d01752b8b896205924 https://doi.org/10.1002/hep.1840070308

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Implication

Experimental study reveals breath tests predict imminent death and reflect functional hepatocyte mass in cirrhotic rats, suggesting serial testing tracks disease severity.

The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: Correlation with morphometric measurement of hepatocyte mass

Discussion

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Implication

Key Points

Cite This Study

The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: Correlation with morphometric measurement of hepatocyte mass

Discussion

Member takes

Implication

Key Points

Cite This Study

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