Key result
Self-reported nocturia was independently associated with a 4.0 mL/min/1.73 m2 decrease in estimated glomerular filtration rate compared to individuals without nocturia.
Why the study?
Previous studies had not examined the association between nocturia and estimated glomerular filtration rate (eGFR).
Is self-reported nocturia associated with a decreased estimated glomerular filtration rate in the general US population?
Cross-Sectional (n=12,265)
Is self-reported nocturia associated with a decreased estimated glomerular filtration rate in the general US population?
Mean Difference: -4 (95% CI -4.6–-3.4)
p-value: p=<0.001
Self-reported nocturia is associated with a dose-dependent decline in estimated glomerular filtration rate in the general US population.
Nocturia may signal lower eGFR in US adults; hypothesis-generating and requires longitudinal confirmation before clinical use.
Nocturia is a manifestation of systemic diseases, in which chronic kidney disease (CKD) is an independent predictor of nocturia due to its osmotic diuretic mechanism. However, to our knowledge, previous studies have not examined the association between nocturia and estimated glomerular filtration rate (eGFR). The purpose of this study was to assess the association between nocturia exposure and eGFR in the general US population. This study presents a cross-sectional analysis of the general US population enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. To account for potential confounding factors, linear regression analysis was conducted to investigate the association between nocturia and eGFR. Stratified analyses and interaction tests were employed to examine the variables of interest. Additionally, sensitivity analyses were conducted across diverse populations. A total of 12,265 individuals were included in the study. After controlling for confounding factors, the results of the linear regression analysis indicated that a single increase in nocturnal voiding frequency was associated with a decrease in eGFR by 2.0 mL/min/1.73 m 2 . In comparison to individuals with a nocturnal urinary frequency of 0, those who voided 1, 2, 3, 4, and ≥ 5 times at night experienced a decrease in eGFR by 3.1, 5.4, 6.4, 8.6 and 4.0 mL/min/1.73 m 2 , respectively. Nocturia was found to be associated with a decreased eGFR of 4 mL/min/1.73 m 2 when compared to individuals without nocturia. The sensitivity analysis yielded consistent findings regarding the association between nocturia and eGFR in both CKD and non-CKD populations, as well as in hypertensive and non-hypertensive populations. Nevertheless, inconsistent conclusions were observed across various prognostic risk populations within the CKD context. The presence of nocturia and heightened frequency of nocturnal urination have been found to be associated with a decline in eGFR.
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Song et al. (2023) conducted a cross-sectional in General population (assessing eGFR and nocturia) (n=12,265). Nocturia vs. No nocturia was evaluated on Estimated glomerular filtration rate (eGFR) (MD -4.0 mL/min/1.73 m2, 95% CI -4.6 to -3.4, p=<0.001). Self-reported nocturia was independently associated with a 4.0 mL/min/1.73 m2 decrease in estimated glomerular filtration rate compared to individuals without nocturia.
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