Key result
Cu,Zn SOD deficiency enhanced myogenic tone in mice compared with controls, particularly in females, eliminating the baseline gender difference where females typically have lower tone than males.
Cu,Zn SOD deficiency enhances vascular myogenic tone and abolishes the protective gender effect in female mice, highlighting the role of oxidative stress in vascular dysfunction.
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Does not alter clinical vascular management; leaves open translation of SOD effects on sex-specific tone to humans.
Veerareddy et al. (2004) studied Oxidative stress and vascular dysfunction. Cu,Zn SOD deficiency (SOD knockout) vs. Wild-type control mice was evaluated on Myogenic tone of resistance-sized mesenteric arteries. Cu,Zn SOD deficiency enhanced myogenic tone in mice compared with controls, particularly in females, eliminating the baseline gender difference where females typically have lower tone than males.