Key result
Z.M.B extract, carvacrol, and thymol markedly decreased the renal index, oxidative stress, and renal tubular necrosis compared with the cisplatin-only group in rats.
Why the study?
Does Zataria multiflora Boiss. extract, carvacrol, or thymol prevent cisplatin-induced nephrotoxicity in rats?
Does Zataria multiflora Boiss. extract, carvacrol, or thymol prevent cisplatin-induced nephrotoxicity in rats?
Zataria multiflora Boiss. extract, carvacrol, and thymol demonstrate renoprotective effects against cisplatin-induced nephrotoxicity in a rat model.
Answers are grounded in this paper and cite their sources.
Animal data are hypothesis-generating; leaves open clinical translation for cisplatin nephrotoxicity prevention.
BACKGROUND: Boiss. hydroalcoholic extract (Z.M.B), carvacrol, and thymol on cisplatin-induced nephrotoxicity in rats. MATERIALS AND METHODS: = 7). Group I received normal saline; group II received Cis (7 mg/kg. ip); group III received the Z.M.B extract only (500 mg/kg/d, po); group IV received Z.M.B extract (500 mg/kg/d, po) + Cis; group V received carvacrol (50 mg/kg/d, po) + Cis; and group VI received thymol (50 mg/kg/d, po) + Cis. The levels of biochemical markers, oxidative stress parameters, and histopathological staining were determined in serum and renal tissues. Also, the chemical compositions (carvacrol and thymol) of the Z.M.B extract were assayed by HPLC analysis. RESULT: The results revealed that Z.M.B extract, carvacrol, and thymol markedly decreased the renal index as compared with the Cis-only group. Also, carvacrol and thymol significantly reduced the blood urea nitrogen level as compared with the Cis-only group. Furthermore, Z.M.B extract, carvacrol, and thymol significantly attenuated the Cis-induced increase in malondialdehyde and nitric oxide metabolite. Additionally, histopathological examination showed that Z.M.B extract, carvacrol, and thymol markedly ameliorated Cis-induced renal tubular necrosis. CONCLUSION: The results showed renoprotective effects of Z.M.B extract, carvacrol, and thymol in Cis-induced nephrotoxicity in rats. Therefore, Z.M.B extract can be considered as a potential candidate for the protection of nephrotoxicity induced by Cis.
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Kokhdan et al. (2021) studied Cisplatin-induced nephrotoxicity. Zataria multiflora Boiss. extract, carvacrol, and thymol vs. Cisplatin only (7 mg/kg) was evaluated on Renal index, blood urea nitrogen, oxidative stress parameters, and histopathological changes. Z.M.B extract, carvacrol, and thymol markedly decreased the renal index, oxidative stress, and renal tubular necrosis compared with the cisplatin-only group in rats.
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