Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2004Kidney & Blood Pressure Research

Protective Effect of Quercetin on the Evolution of Cisplatin-Induced Acute Tubular Necrosis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does quercetin reduce cisplatin-induced acute tubular necrosis in a rat model?

Population

103 male Wistar rats injected with cisplatin (5 mg/kg, i.p.)

Comparison

Quercetin administered before cisplatin injection vs Cisplatin injection without quercetin

Design

Preclinical

Follow-up

20 days

Authors

HFHeloı́sa Della Coletta FrancescatoTCTerezila Machado CoimbraRCRoberto Silva Costa

Discussion

Loading...

Member takes

Overview

Supports further preclinical quercetin research for cisplatin nephroprotection; leaves open clinical translation and should not change practice.

Structured PICO

Does quercetin reduce cisplatin-induced acute tubular necrosis in a rat model?

P
Population
103 male Wistar rats injected with cisplatin (5 mg/kg, i.p.)
I
Intervention
Quercetin (50 mg/kg, by gavage) administered before cisplatin injection
C
Comparator
Cisplatin injection without quercetin
O
Outcome
Functional, histological and immunohistochemical alterations (plasma creatinine, urine volume and osmolality, renal malondialdehyde, and expression of fibronectin, alpha-smooth muscle actin, vimentin, Jun N-terminal kinase, nuclear factor-kappaB, and macrophages) at 5 and 20 dayssurrogate

In a rat model, prophylactic administration of quercetin attenuated cisplatin-induced acute tubular necrosis and associated functional and histological changes.

Cite This Study

Francescato et al. (2004) studied this question.

synapsesocial.com/papers/6a900905e16d749e8fc90e27https://doi.org/10.1159/000078309
View Full Paper
Ask AI
Bookmark
Share