Key result
Curcumin prevents rising serum urea, creatinine, and malondialdehyde levels in rats with cisplatin-induced nephrotoxicity.
Why the study?
Does curcumin prevent cisplatin-induced nephrotoxicity in male Wistar rats?
Population
Male Wistar rats
Comparison
Curcumin combined with cisplatin vs Control group, cisplatin-only group, and…
Design
Preclinical, divided into four groups
Follow-up
10 days
Authors
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May support curcumin in rat cisplatin nephrotoxicity; leaves open human translation.
Does curcumin prevent cisplatin-induced nephrotoxicity in male Wistar rats?
p-value: p=<0.05
Curcumin demonstrates renoprotective effects against cisplatin-induced nephrotoxicity in a rat model, potentially by modulating stress resistance and cell death pathways.
Ugur et al. (2015) studied Cisplatin-induced nephrotoxicity. Curcumin vs. Control and cisplatin-only groups was evaluated on Serum urea, creatinine, and malondialdehyde (MDA) levels (p=<0.05). Curcumin treatment prevented the rise in serum urea, creatinine, and malondialdehyde levels in rats with cisplatin-induced nephrotoxicity (p<0.05).
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