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July 26, 2026Immunopharmacology and Immunotoxicology

Quinic acid attenuates cisplatin-induced AKI by restoring antioxidant capacity and reducing inflammation.

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Why the study?

Cisplatin-induced nephrotoxicity limits its clinical utility, and quinic acid has cytoprotective and antioxidant properties that may protect against acute kidney injury.

Does quinic acid attenuate cisplatin-induced acute kidney injury in a rat model?

Population

Forty male Wistar rats

Comparison

Control vs cisplatin alone vs cisplatin plus quinic acid (25, 50, or 100 mg/kg)

Design

Randomized animal study with blinded histopathology scoring

Key result

Quinic acid (particularly at 50 and 100 mg/kg) significantly attenuated cisplatin-induced acute kidney injury by improving renal markers, restoring antioxidant capacity, and reducing inflammation.

Authors

MGMehdi GoudarziZLZohreh LamoochiSSSusan Sabbagh

Discussion

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Overview

QA attenuates cisplatin AKI in rats; leaves open translation to human chemotherapy patients.

Key Points

  • This study aims to assess the protective effect of quinic acid against cisplatin-induced acute kidney injury in rats.
  • Forty male Wistar rats were randomly divided into five groups (n=8) including control and treatment groups.
  • Cisplatin was administered at 7.5 mg/kg, with quinic acid given at 25, 50, or 100 mg/kg orally for 14 days prior to cisplatin administration.
  • Biochemical markers, oxidative stress indices, inflammatory cytokines, and apoptotic gene expression were assessed.
  • Cisplatin caused severe renal dysfunction and increased oxidative stress, inflammation, and apoptosis.
  • Quinic acid significantly improved renal markers, reduced oxidative stress (MDA, NO), and downregulated inflammatory cytokines (TNF-α, IL-1β).
  • Higher doses of quinic acid enhanced Nrf2-pathway protein levels and reduced histological injury scores significantly.

Study Design

Type

RCT (n=40)

Blinding

Single-blind

Randomization

Randomly divided

Structured PICO

Does quinic acid attenuate cisplatin-induced acute kidney injury in a rat model?

P
Population
40 male Wistar rats subjected to cisplatin-induced acute kidney injury, treated with quinic acid for 14 days prior to cisplatin challenge.
I
Intervention
Quinic acid (QA) administered orally at doses of 25, 50, or 100 mg/kg once daily for 14 days before cisplatin challenge (7.5 mg/kg, i.p.)
C
Comparator
Cisplatin alone (7.5 mg/kg, i.p.) and untreated control
O
Outcome
Biochemical markers of renal injury (BUN, creatinine, KIM-1, NGAL), oxidative stress indices, inflammatory cytokines, apoptotic gene expression, Nrf2 pathway proteins, and renal histopathologysurrogate

Quinic acid demonstrates nephroprotective effects against cisplatin-induced acute kidney injury in rats through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.

Cite This Study

Goudarzi et al. (2026) conducted an RCT in Cisplatin-induced acute kidney injury (n=40). Quinic acid vs. Cisplatin alone and healthy control was evaluated on Biochemical markers of renal dysfunction, oxidative stress indices, inflammatory cytokines, apoptotic gene expression, and Nrf2 pathway proteins. Quinic acid (particularly at 50 and 100 mg/kg) significantly attenuated cisplatin-induced acute kidney injury by improving renal markers, restoring antioxidant capacity, and reducing inflammation.

synapsesocial.com/papers/6a65a91fd3aea3239cd79281https://doi.org/10.1080/08923973.2026.2705914
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protective Effect of Quercetin on the Evolution of Cisplatin-Induced Acute Tubular Necrosis2004 · 69 citations
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