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November 1, 2025International Journal of Nephrology and Renovascular DiseaseOpen Access

Preclinical studies demonstrate consistent nephroprotective effects of NAC, but clinical findings remain inconsistent due to limited sample sizes, varied dosing regimens, and differences in administration routes.

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Why the study?

Cisplatin use is limited by dose-dependent nephrotoxicity causing acute kidney injury in up to 45% of patients, and current preventive strategies provide questionable outcomes.

Does N-acetylcysteine prevent cisplatin-induced acute kidney injury in cancer patients receiving cisplatin-based chemotherapy?

Design

Narrative review of preclinical and clinical studies

Authors

OPOryza Gryagus PrabuNINabilah Nurul IslamiJMJesslyn Mellenia

Discussion

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Member takes

Overview

NAC remains promising for cisplatin-AKI prevention; leaves open confirmation in large randomized trials.

Structured PICO

Does N-acetylcysteine prevent cisplatin-induced acute kidney injury in cancer patients receiving cisplatin-based chemotherapy?

P
Population
Cancer patients receiving cisplatin-based chemotherapy
I
Intervention
N-acetylcysteine (NAC)
O
Outcome
Prevention of cisplatin-induced acute kidney injury (AKI)safety

N-acetylcysteine shows promise in preclinical models for preventing cisplatin-induced AKI, but clinical evidence remains inconsistent and requires further standardized trials.

Limitations

  • limited sample sizes in clinical studies
  • varied dosing regimens
  • differences in administration routes

Cite This Study

Prabu et al. (2025) studied this question.

synapsesocial.com/papers/6a782e412ea07b97ffae13d4https://doi.org/10.2147/ijnrd.s563298
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of N-Acetylcysteine on Cisplatin Toxicity: A Review of the Literature2024 · 21 citations
  2. 2N-acetylcysteine Attenuates Cisplatin Toxicity in Cerebrum and Lung of Young Rats with Artificially Produced Protein Deficiency2024 · 1 citations
  3. 3The effects of N-acetylcysteine on cisplatin induced cardiotoxicity2019 · 27 citations
  4. 4Possible mechanisms for N-acetyl cysteine and taurine in ameliorating acute renal failure induced by cisplatin in rats2011 · 36 citations
  5. 5Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency2017 · 23 citations