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January 1, 2024BiologicsOpen Access

Late administration of NAC after cisplatin reduces side effects caused by various toxicities without affecting the antitumor efficacy of platinum.

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Why the study?

Cisplatin is widely used in adults and children, but causes toxicities that may be reduced by the potential chemoprotectant N-acetylcysteine.

Does N-acetylcysteine reduce cisplatin toxicity in adults and children receiving cisplatin treatment?

Comparison

N-acetylcysteine administration after cisplatin vs cisplatin alone

Design

Literature review

Authors

AZAngeles Citlali Zavala-ValenciaLVLiliana Velasco‐HidalgoAMArmando Martínez‐Avalos

Discussion

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Overview

Late NAC may reduce cisplatin toxicities without compromising efficacy; leaves open clinical translation.

Structured PICO

Does N-acetylcysteine reduce cisplatin toxicity in adults and children receiving cisplatin treatment?

P
Population
Adults and children receiving cisplatin treatment, as well as in vivo models of cisplatin toxicity
I
Intervention
N-acetylcysteine (NAC)
O
Outcome
Cisplatin toxicity and side effectssafety

N-acetylcysteine represents a potential chemoprotective agent to decrease toxicities secondary to cisplatin treatment without compromising its antitumor efficacy.

Cite This Study

Zavala-Valencia et al. (2024) studied this question.

synapsesocial.com/papers/6a7e67108d19188c2c856bbehttps://doi.org/10.2147/btt.s438150
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1N-Acetylcysteine Role in Maintaining Renal Function in Cancer Patients with Cisplatin-Based Chemotherapy2025 · 2 citations
  2. 2N-acetylcysteine Attenuates Cisplatin Toxicity in Cerebrum and Lung of Young Rats with Artificially Produced Protein Deficiency2024 · 1 citations
  3. 3The effects of N-acetylcysteine on cisplatin induced cardiotoxicity2019 · 27 citations
  4. 4N-Acetylcysteine Attenuates Cisplatin Toxicity in the Cerebrum and Lung of Young Rats with Artificially Induced Protein Deficiency2024 · 3 citations
  5. 5Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency2017 · 23 citations