Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2019Bratislavské lekárske listy/Bratislava medical journalOpen Access

NAC administration after cisplatin significantly reduced plasma cTnI (154.5 vs 305.5 pg/mL, p<0.05) and CMLC-1 (5.82 vs 15.45 ng/mL, p<0.05) compared to cisplatin alone, alongside improvements in oxidative stress and histological markers.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Oxidative stress contributes to cisplatin-induced cardiotoxicity, prompting investigation into the protective effects of the antioxidant N-acetylcysteine.

Does N-acetylcysteine reduce cisplatin-induced cardiotoxicity in a rat model?

Comparison

Control vs NAC-250 vs cisplatin vs cisplatin plus NAC

Design

Animal experimental study

Authors

EGE. E. GunturkBYBirsen YücelİGİnayet Güntürk

Discussion

Loading...

Member takes

Overview

NAC may attenuate cisplatin cardiotoxicity in rats; leaves open translation to human cardioprotection.

Structured PICO

Does N-acetylcysteine reduce cisplatin-induced cardiotoxicity in a rat model?

P
Population
32 male Wistar albino rats, aged 24 weeks, weighing 350-400 g.
I
Intervention
N-acetylcysteine (NAC) 250 mg/kg intraperitoneally for 3 consecutive days, administered 4 hours after a single dose of cisplatin (10 mg/kg ip).
C
Comparator
Control (saline 1 mL/kg ip), Cisplatin alone (10 mg/kg ip single dose), and NAC alone (250 mg/kg ip for 3 days).
O
Outcome
Cardiotoxicity assessed by plasma CK-MB, LDH, cTnI, and CMLC-1 levels, tissue oxidative stress markers (TOC, TAC, ROOH, thiol), and histopathological scoring at the end of the 3-day experiment.surrogate

N-acetylcysteine partially ameliorates cisplatin-induced cardiotoxicity and oxidative stress in a rat model, suggesting potential as an adjunctive cardioprotective agent.

Limitations

  • NAC at doses of 250 mg/kg did not completely prevent the cardiac injury resulting from cisplatin-induced oxidative cardiac toxicity.
  • Unexplained increase in cTnI and mild histological damage in the NAC-alone group.

Cite This Study

Gunturk et al. (2019) studied this question.

synapsesocial.com/papers/6a75fbe79aebbbed366136c6https://doi.org/10.4149/bll_2019_068
View Full Paper
Ask AI
Bookmark
Share