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April 7, 2011Toxicology Mechanisms and Methods

Treatment with N-acetyl cysteine or taurine significantly ameliorated cisplatin-induced oxidative stress markers and inflammation in rats.

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Why the study?

Does N-acetyl cysteine or taurine ameliorate acute renal failure induced by cisplatin in rats?

Population

Rats with cisplatin-induced acute renal failure

Comparison

N-acetyl cysteine or taurine 50 mg/kg IP 3 times… vs Cisplatin-treated group without NAC/TAU and…

Design

Preclinical

Follow-up

8 weeks

Key result

Treatment with N-acetyl cysteine or taurine significantly ameliorated cisplatin-induced oxidative stress markers and inflammation in rats.

Authors

ASAziza B. ShalbyNANaglaa AssafHAHanaa Hamdy Ahmed

Discussion

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Overview

Should not change clinical practice for cisplatin nephrotoxicity; hypothesis-generating in rat models and requires human trials.

Structured PICO

Does N-acetyl cysteine or taurine ameliorate acute renal failure induced by cisplatin in rats?

P
Population
Rats with cisplatin-induced acute renal failure treated with N-acetyl cysteine or taurine for 8 weeks.
I
Intervention
N-acetyl cysteine (NAC) or taurine (TAU) 50 mg/kg IP 3 times weekly for 8 weeks
C
Comparator
Cisplatin-treated group without NAC/TAU and normal controls
O
Outcome
Nephrotoxicity markers including blood urea, creatinine, β(2)-MG, N-acetyl-β-glucosaminidase, histology scores, oxidative stress, and inflammatory biomarkerssurrogate

N-acetyl cysteine and taurine demonstrate antioxidant and anti-inflammatory effects that ameliorate cisplatin-induced nephrotoxicity in a rat model.

Cite This Study

Shalby et al. (2011) studied Cisplatin-induced acute renal failure. N-acetyl cysteine (NAC) or taurine (TAU) vs. Cisplatin-treated control group was evaluated on Nephrotoxicity (blood urea, creatinine, oxidative stress markers, and inflammation). Treatment with N-acetyl cysteine or taurine significantly ameliorated cisplatin-induced oxidative stress markers and inflammation in rats.

synapsesocial.com/papers/6ab5cda06d8ba6b22a563f3dhttps://doi.org/10.3109/15376516.2011.568985
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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