April 30, 2026International Journal of Molecular SciencesOpen Access

The Protective Effects of N-Acetylserotonin Against Cisplatin-Induced Renal Injury: A Biochemical and Histopathological Study

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SYSelçuk Yazıcı GTGülay TuranBalıkesir University MYMerve Akis YilmazBalıkesir University

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Implication

Biochemical evaluation shows NAS treatment reduces nephrotoxicity and aids renal function in cisplatin-exposed rats, suggesting therapeutic potential.

Key Points

To assess the protective effects of N-acetylserotonin against cisplatin-induced acute kidney injury in a rat model.
Conducted a biochemical and histopathological study using 35 Wistar Albino rats divided into five treatment groups.
Administered N-acetylserotonin and cisplatin to evaluate their effects on renal function and oxidative stress markers.
Measured serum urea, creatinine, and various oxidative stress markers in kidney tissue.
Performed histopathological evaluations to assess renal damage.
Cisplatin significantly increased serum creatinine levels, indicating renal injury.
NAS treatment reduced histopathological damage, including tubular and glomerular degeneration.
Treatment with NAS showed a trend toward biochemical recovery in oxidative stress markers, though not statistically significant.

Cite This Study

Yazıcı et al. (2026) studied this question.

synapsesocial.com/papers/69f2a4578c0f03fd6776360f https://doi.org/10.3390/ijms27093896

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April 30, 2026International Journal of Molecular SciencesOpen Access

The Protective Effects of N-Acetylserotonin Against Cisplatin-Induced Renal Injury: A Biochemical and Histopathological Study

View Full Paper

Ask AI

Bookmark

Authors

SYSelçuk Yazıcı GTGülay TuranBalıkesir University MYMerve Akis YilmazBalıkesir University

Discussion

Member takes

Implication

Biochemical evaluation shows NAS treatment reduces nephrotoxicity and aids renal function in cisplatin-exposed rats, suggesting therapeutic potential.

Key Points

To assess the protective effects of N-acetylserotonin against cisplatin-induced acute kidney injury in a rat model.
Conducted a biochemical and histopathological study using 35 Wistar Albino rats divided into five treatment groups.
Administered N-acetylserotonin and cisplatin to evaluate their effects on renal function and oxidative stress markers.
Measured serum urea, creatinine, and various oxidative stress markers in kidney tissue.
Performed histopathological evaluations to assess renal damage.
Cisplatin significantly increased serum creatinine levels, indicating renal injury.
NAS treatment reduced histopathological damage, including tubular and glomerular degeneration.
Treatment with NAS showed a trend toward biochemical recovery in oxidative stress markers, though not statistically significant.

Cite This Study

Yazıcı et al. (2026) studied this question.

synapsesocial.com/papers/69f2a4578c0f03fd6776360f https://doi.org/10.3390/ijms27093896

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