Key result
Acetyl L-carnitine administration prior to cisplatin improved kidney function tests and decreased apoptotic cell death and caspase activities compared to cisplatin alone in rats.
Why the study?
Does acetyl L-carnitine prevent cisplatin-induced nephrotoxicity in Wistar rats?
Population
28 Wistar rats
Comparison
Acetyl L-carnitine administered prior to cisplatin vs Cisplatin alone, ALCAR alone, and saline only
Design
Preclinical
Follow-up
72 hours
Authors
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Supports preclinical renoprotection research; leaves open translation to human cisplatin recipients.
Does acetyl L-carnitine prevent cisplatin-induced nephrotoxicity in Wistar rats?
Acetyl L-carnitine demonstrates antioxidative, antiapoptotic, and anti-inflammatory properties that protect against cisplatin-induced nephrotoxicity in a rat model.
Tüfekçi et al. (2009) studied Cisplatin-induced nephrotoxicity (n=28). Acetyl L-carnitine (ALCAR) vs. Cisplatin alone was evaluated on Kidney function tests, histopathological findings, apoptotic cell death, and caspase-3, 8 and 9 activities. Acetyl L-carnitine administration prior to cisplatin improved kidney function tests and decreased apoptotic cell death and caspase activities compared to cisplatin alone in rats.
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