What question did this study set out to answer?

Provide an updated, evidence-based international consensus guideline for identifying patient risk factors, implementing baseline risk reduction, and managing postoperative and postdischarge nausea and vomiting in adult and pediatric populations.

November 14, 2025Anesthesia & Analgesia

Fifth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting: Executive Summary

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Authors

TGTong J. GanShenyang Aerospace University ZJZhaosheng JinStony Brook School SASabry AyadCleveland Clinic

Discussion

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Implication

Consensus guideline demonstrates multimodal antiemetic prophylaxis reduces postoperative nausea and vomiting in surgical patients, highlighting risk-stratified perioperative pathways.

Key Points

Provide an updated, evidence-based international consensus guideline for identifying patient risk factors, implementing baseline risk reduction, and managing postoperative and postdischarge nausea and vomiting in adult and pediatric populations.
Conducted systematic literature searches following Cochrane Handbook, PRISMA 2020, and PRISMA-S methodologies.
Graded the quality of retrieved clinical evidence using the American Society of Anesthesiologists acute pain management guideline grading system.
Validated risk scoring systems such as the Apfel simplified score stratify baseline risk from approximately 10% to 80% across 0 to 4 risk factors to guide intervention.
Baseline risk reduction strategies, notably propofol total intravenous anesthesia, multimodal opioid-sparing analgesia, and regional blocks, effectively decrease postoperative emesis.
Multimodal prophylactic combinations uniting distinct antiemetic drug classes, including 5-HT3 receptor antagonists, dexamethasone, and droperidol or neurokinin-1 antagonists, confer superior protection compared to monotherapy.

Cite This Study

Gan et al. (2025) studied this question.

synapsesocial.com/papers/6a93329db34be631875d010d https://doi.org/10.1213/ane.0000000000007816

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Implication

Consensus guideline demonstrates multimodal antiemetic prophylaxis reduces postoperative nausea and vomiting in surgical patients, highlighting risk-stratified perioperative pathways.

Fifth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting: Executive Summary

Discussion

Member takes

Implication

Key Points

Cite This Study

Fifth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting: Executive Summary

Discussion

Member takes

Implication

Key Points

Cite This Study

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