Key result
High-dose inhaled corticosteroids did not significantly affect lumbar spine bone density compared to low-dose or no use (0.94 vs 0.96 g/cm2; p>0.05) over a 3-year period.
Why the study?
Does high-dose inhaled corticosteroids reduce bone density compared to low-dose or no use in patients treated for more than 5 years?
Population
51 patients (37 male, 14 female) using beclomethasone or budesonide for more than 5 years
Comparison
Beclomethasone or budesonide at a daily dose >… vs No or < 500 microgram/d of beclomethasone or…
Design
Cohort
Follow-up
3 years
Authors
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No significant BMD difference with high-dose ICS over 3 years; leaves open longer-term effects beyond 5 years and requires randomized confirmation.
Cohort (n=51)
Does high-dose inhaled corticosteroids reduce bone density compared to low-dose or no use in patients treated for more than 5 years?
Absolute Event Rate: 0.94% vs 0.96%
p-value: p=> 0.05
Long-term use of high-dose inhaled corticosteroids does not significantly reduce lumbar spine bone density compared to low-dose or no use over a 3-year period.
Boulet et al. (1999) conducted a cohort in Patients using inhaled corticosteroids (n=51). High-dose inhaled corticosteroids vs. No or < 500 microgram/d inhaled corticosteroids was evaluated on Lumbar spine bone density (p=> 0.05). High-dose inhaled corticosteroids did not significantly affect lumbar spine bone density compared to low-dose or no use (0.94 vs 0.96 g/cm2; p>0.05) over a 3-year period.
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