Key result
Propofol achieved successful anesthesia induction significantly faster than ciprofol (MD 0.08 min), although both agents demonstrated comparable overall efficacy and safety profiles.
Why the study?
Although propofol is the gold standard for anesthesia induction and maintenance, the search for alternatives with improved safety and efficacy led to ciprofol, requiring a comprehensive assessment comparing them.
Does ciprofol improve safety and efficacy compared to propofol for anesthesia induction and maintenance in adult patients undergoing surgical procedures?
Meta-Analysis (n=714)
Does ciprofol improve safety and efficacy compared to propofol for anesthesia induction and maintenance in adult patients undergoing surgical procedures?
Ciprofol and propofol demonstrate comparable efficacy and safety for general anesthesia, with propofol offering faster induction and ciprofol causing less injection-site pain.
This is the authors' abstract. We don't add key points for this paper.
BACKGROUND: Propofol has been the gold standard for anesthesia induction and maintenance due to its rapid onset and favorable pharmacokinetic properties. However, the search for alternative agents with improved safety and efficacy has led to the emergence of ciprofol (HSK3486), a structural analog of propofol. This systematic review and meta-analysis aim to comprehensively assess the safety and efficacy of ciprofol compared to propofol for anesthesia induction and maintenance in adult patients undergoing surgical procedures. METHODS: This study included only double-arm RCTs in which participants were aged eighteen or older undergoing surgery. For the statistical analysis of the extracted data, we employed RevMan 5.4.1. RESULTS: Ciprofol demonstrated a promising trend of higher anesthesiologists' satisfaction during the induction phase (MD 0.14, 95%, CI - 0.28 to 0.56, p = 0.51), whereas Propofol was favored during maintenance. Propofol also exhibited advantages with a shorter time to successful anesthesia induction (MD 0.08 min, 95% CI 0.00 to 0.15, p = 0.04), and quicker attainment of full alertness (MD 0.11 min, 95% CI - 1.29 to 1.52, p = 0.87), suggesting its efficiency in clinical practice. Importantly, there were no significant disparities in the success rate of anesthesia. CONCLUSION: Both ciprofol and propofol demonstrate comparable efficacy and safety for anesthesia induction and maintenance in adult patients undergoing surgery. While propofol provides a faster onset of induction, ciprofol exhibits advantages in terms of pain management. Clinicians should consider these findings when selecting anesthetic agents, and tailoring choices to individual patient needs and clinical scenarios.
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Ciprofol matches propofol in efficacy and safety for induction and maintenance; extends RCT evidence supporting its use as an alternative with less injection pain.
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Hudaib et al. (2024) conducted a meta-analysis in General anesthesia for surgical procedures (n=714). Ciprofol vs. Propofol was evaluated on Time to successful anesthesia induction (MD 0.08, 95% CI 0.00 to 0.15, p=0.04). Propofol achieved successful anesthesia induction significantly faster than ciprofol (MD 0.08 min), although both agents demonstrated comparable overall efficacy and safety profiles.
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