August 1, 2001Journal of Hypertension
The spectrum of circadian blood pressure changes in type I diabetic patients
Key result
A non-dipping blood pressure pattern was observed in 80% of proteinuric, 58% of microalbuminuric, and 18% of normoalbuminuric type I diabetics, compared to 10% of matched controls.
Population
80 type I diabetic subjects and 80 age, sex, and awake mean blood pressure-matched controls.
Design
Case-control
Authors
Discussion
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Implication
Non-dipping BP pattern associates with albuminuria severity in type 1 diabetes; leaves open prospective validation for ambulatory monitoring in risk stratification.
Study Design
Type
Case-Control (n=160)
Structured PICO
P
Population
160 subjects including 80 type I diabetics at different stages of nephropathy and 80 age-, sex-, and awake mean BP-matched controls.
C
Comparator
Age, sex, and awake mean blood pressure-matched controls
O
Outcome
Circadian blood pressure changes (blood pressure and heart rate averages during 24 h, awake, sleep, and day:night ratio)surrogate
Persistent abnormal circadian blood pressure variability (non-dipping pattern) is an early and frequent characteristic of type I diabetics that increases in frequency as incipient nephropathy progresses.
Cite This Study
Lurbe et al. (2001) conducted a case-control in Type I diabetes (n=160). Type I diabetes with varying stages of nephropathy vs. Age, sex and awake mean BP-matched controls was evaluated on Non-dipping blood pressure pattern. A non-dipping blood pressure pattern was observed in 80% of proteinuric, 58% of microalbuminuric, and 18% of normoalbuminuric type I diabetics, compared to 10% of matched controls.