Key result
A physiologically realistic model of microcirculatory water and solute exchange was developed and found to be consistent with diverse experimental observations in the heart.
A new physiologically realistic computational model successfully unifies diverse observations of water and solute exchange in the heart.
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Provides a platform for simulating cardiac microcirculatory exchange; leaves open translation to human disease and clinical relevance.
Physiologists have devised many models for interpreting water and solute exchange data in whole organs, but the models have typically neglected key aspects of the underlying physiology to present the simplest possible model for a given experimental situation. We have developed a physiologically realistic model of microcirculatory water and solute exchange and applied it to diverse observations of water and solute exchange in the heart. Model simulations are consistent with the results of osmotic weight transient, tracer indicator dilution, and steady-state lymph sampling experiments. The key model features that permit this unification are the use of an axially distributed blood-tissue exchange region, inclusion of a lymphatic drain in the interstitium, and the independent computation of transcapillary solute and solvent fluxes through three different pathways.
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Kellen et al. (2003) studied Microcirculatory water and solute exchange in the heart. Physiologically realistic model of microcirculatory water and solute exchange was evaluated on Consistency of model simulations with experimental data. A physiologically realistic model of microcirculatory water and solute exchange was developed and found to be consistent with diverse experimental observations in the heart.
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